PhanerochaeteV1, Main, Exploration, bibRecord, 000187

Biodegradation of micropollutant naproxen with a selected fungal strain and identification of metabolites.

Identifieur interne : 000187 ( Main/Exploration ); précédent : 000186; suivant : 000188

Biodegradation of micropollutant naproxen with a selected fungal strain and identification of metabolites.

Auteurs : Y Doruk Aracagök ; Hakan Göker ; Nilüfer Cihangir

Source :

Zeitschrift fur Naturforschung. C, Journal of biosciences [ 0939-5075 ] ; 2017.

RBID : pubmed:27831926

Descripteurs français

English descriptors

KwdEn :
- Anti-Inflammatory Agents, Non-Steroidal (adverse effects), Anti-Inflammatory Agents, Non-Steroidal (metabolism), Aspergillus niger (enzymology), Biodegradation, Environmental (MeSH), Biotransformation (MeSH), Carbon-13 Magnetic Resonance Spectroscopy (MeSH), Chromatography, Liquid (MeSH), Cytochrome P-450 Enzyme System (metabolism), Fungal Proteins (metabolism), Hydroxylation (MeSH), Mass Spectrometry (MeSH), Naproxen (adverse effects), Naproxen (analogs & derivatives), Naproxen (metabolism), Phanerochaete (enzymology), Proton Magnetic Resonance Spectroscopy (MeSH), Water Pollutants, Chemical (adverse effects), Water Pollutants, Chemical (metabolism), Water Purification (methods), Yarrowia (enzymology).
MESH :
- chemical , adverse effects : Anti-Inflammatory Agents, Non-Steroidal, Naproxen, Water Pollutants, Chemical.
- chemical , analogs & derivatives : Naproxen.
- chemical , metabolism : Anti-Inflammatory Agents, Non-Steroidal, Cytochrome P-450 Enzyme System, Fungal Proteins, Naproxen, Water Pollutants, Chemical.
- enzymology : Aspergillus niger, Phanerochaete, Yarrowia.
- methods : Water Purification.
- Biodegradation, Environmental, Biotransformation, Carbon-13 Magnetic Resonance Spectroscopy, Chromatography, Liquid, Hydroxylation, Mass Spectrometry, Proton Magnetic Resonance Spectroscopy.

Abstract

Pharmaceuticals are widely used for treating human and animal diseases. Naproxen [(S) 6-methoxy-α-methyl-2-naphthalene acetic acid] and its sodium salt are members of the α-arylpropionic acid group of nonsteroidal anti-inflammatory drugs. Due to excessive usage of naproxen, this drug has been determined even in drinking water. In this study, four fungal strains Phanerochaete chrysosporium, Funalia trogii, Aspergillus niger, and Yarrowia lipolytica were investigated in terms of naproxen removal abilities. According to LC/MS data, A. niger was found the most efficient strain with 98% removal rate. Two main by-products of fungal transformation, O-desmethylnaproxen and 7-hydroxynaproxen, were identified by using LC/MS, 1HNMR, and 13CNMR. Our results showed that O-demethylation and hydroxylation of naproxen is catalyzed by cytochrome P450 enzyme system.

DOI: 10.1515/znc-2016-0162
PubMed: 27831926

Affiliations:

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Le document en format XML

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<term>Anti-Inflammatory Agents, Non-Steroidal (metabolism)</term>
<term>Aspergillus niger (enzymology)</term>
<term>Biodegradation, Environmental (MeSH)</term>
<term>Biotransformation (MeSH)</term>
<term>Carbon-13 Magnetic Resonance Spectroscopy (MeSH)</term>
<term>Chromatography, Liquid (MeSH)</term>
<term>Cytochrome P-450 Enzyme System (metabolism)</term>
<term>Fungal Proteins (metabolism)</term>
<term>Hydroxylation (MeSH)</term>
<term>Mass Spectrometry (MeSH)</term>
<term>Naproxen (adverse effects)</term>
<term>Naproxen (analogs & derivatives)</term>
<term>Naproxen (metabolism)</term>
<term>Phanerochaete (enzymology)</term>
<term>Proton Magnetic Resonance Spectroscopy (MeSH)</term>
<term>Water Pollutants, Chemical (adverse effects)</term>
<term>Water Pollutants, Chemical (metabolism)</term>
<term>Water Purification (methods)</term>
<term>Yarrowia (enzymology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Anti-inflammatoires non stéroïdiens (effets indésirables)</term>
<term>Anti-inflammatoires non stéroïdiens (métabolisme)</term>
<term>Aspergillus niger (enzymologie)</term>
<term>Biotransformation (MeSH)</term>
<term>Chromatographie en phase liquide (MeSH)</term>
<term>Cytochrome P-450 enzyme system (métabolisme)</term>
<term>Dépollution biologique de l'environnement (MeSH)</term>
<term>Hydroxylation (MeSH)</term>
<term>Naproxène (analogues et dérivés)</term>
<term>Naproxène (effets indésirables)</term>
<term>Naproxène (métabolisme)</term>
<term>Phanerochaete (enzymologie)</term>
<term>Polluants chimiques de l'eau (effets indésirables)</term>
<term>Polluants chimiques de l'eau (métabolisme)</term>
<term>Protéines fongiques (métabolisme)</term>
<term>Purification de l'eau (méthodes)</term>
<term>Spectrométrie de masse (MeSH)</term>
<term>Spectroscopie par résonance magnétique du carbone-13 (MeSH)</term>
<term>Spectroscopie par résonance magnétique du proton (MeSH)</term>
<term>Yarrowia (enzymologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Anti-Inflammatory Agents, Non-Steroidal</term>
<term>Naproxen</term>
<term>Water Pollutants, Chemical</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Naproxen</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Anti-Inflammatory Agents, Non-Steroidal</term>
<term>Cytochrome P-450 Enzyme System</term>
<term>Fungal Proteins</term>
<term>Naproxen</term>
<term>Water Pollutants, Chemical</term>
</keywords>
<keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Naproxène</term>
</keywords>
<keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Anti-inflammatoires non stéroïdiens</term>
<term>Naproxène</term>
<term>Polluants chimiques de l'eau</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Aspergillus niger</term>
<term>Phanerochaete</term>
<term>Yarrowia</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Aspergillus niger</term>
<term>Phanerochaete</term>
<term>Yarrowia</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Water Purification</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Anti-inflammatoires non stéroïdiens</term>
<term>Cytochrome P-450 enzyme system</term>
<term>Naproxène</term>
<term>Polluants chimiques de l'eau</term>
<term>Protéines fongiques</term>
</keywords>
<keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Purification de l'eau</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Biodegradation, Environmental</term>
<term>Biotransformation</term>
<term>Carbon-13 Magnetic Resonance Spectroscopy</term>
<term>Chromatography, Liquid</term>
<term>Hydroxylation</term>
<term>Mass Spectrometry</term>
<term>Proton Magnetic Resonance Spectroscopy</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Biotransformation</term>
<term>Chromatographie en phase liquide</term>
<term>Dépollution biologique de l'environnement</term>
<term>Hydroxylation</term>
<term>Spectrométrie de masse</term>
<term>Spectroscopie par résonance magnétique du carbone-13</term>
<term>Spectroscopie par résonance magnétique du proton</term>
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<front><div type="abstract" xml:lang="en">Pharmaceuticals are widely used for treating human and animal diseases. Naproxen [(S) 6-methoxy-α-methyl-2-naphthalene acetic acid] and its sodium salt are members of the α-arylpropionic acid group of nonsteroidal anti-inflammatory drugs. Due to excessive usage of naproxen, this drug has been determined even in drinking water. In this study, four fungal strains Phanerochaete chrysosporium, Funalia trogii, Aspergillus niger, and Yarrowia lipolytica were investigated in terms of naproxen removal abilities. According to LC/MS data, A. niger was found the most efficient strain with 98% removal rate. Two main by-products of fungal transformation, O-desmethylnaproxen and 7-hydroxynaproxen, were identified by using LC/MS, 1HNMR, and 13CNMR. Our results showed that O-demethylation and hydroxylation of naproxen is catalyzed by cytochrome P450 enzyme system.</div>
</front>
</TEI>
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<Abstract><AbstractText>Pharmaceuticals are widely used for treating human and animal diseases. Naproxen [(S) 6-methoxy-α-methyl-2-naphthalene acetic acid] and its sodium salt are members of the α-arylpropionic acid group of nonsteroidal anti-inflammatory drugs. Due to excessive usage of naproxen, this drug has been determined even in drinking water. In this study, four fungal strains Phanerochaete chrysosporium, Funalia trogii, Aspergillus niger, and Yarrowia lipolytica were investigated in terms of naproxen removal abilities. According to LC/MS data, A. niger was found the most efficient strain with 98% removal rate. Two main by-products of fungal transformation, O-desmethylnaproxen and 7-hydroxynaproxen, were identified by using LC/MS, 1HNMR, and 13CNMR. Our results showed that O-demethylation and hydroxylation of naproxen is catalyzed by cytochrome P450 enzyme system.</AbstractText>
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<QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">7-hydroxynaproxen</Keyword>
<Keyword MajorTopicYN="N">Aspergillus niger</Keyword>
<Keyword MajorTopicYN="N">O-desmethylnaproxen</Keyword>
<Keyword MajorTopicYN="N">biodegradation</Keyword>
<Keyword MajorTopicYN="N">fungal cytochrome P450</Keyword>
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<tree><noCountry><name sortKey="Aracagok, Y Doruk" sort="Aracagok, Y Doruk" uniqKey="Aracagok Y" first="Y Doruk" last="Aracagök">Y Doruk Aracagök</name>
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Biodegradation of micropollutant naproxen with a selected fungal strain and identification of metabolites.

Biodegradation of micropollutant naproxen with a selected fungal strain and identification of metabolites.

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Abstract

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